Problem modify ePub index

I have a new ePub. I put into my iPad. But index isn't perfect, now I delete my ePub, I modify index with calibre and I put into my iPad.
But my iPad don't see my new index (modify with calibre) but the old index (before my new modify)... why?
iPad remember old ePub? I have close iBook, reset my iPad, clean cache with another program (syncios) but never...iPad see old index on my new ePub!