Can'r convert PDF

I'm using Calibre 1.48 on Windows XP. When I try to convert a PDF, I get the error message Failed:Convert Book 1 of 1 ([name]). The detail has the following error at the end:
IOError: [Errno 13] Permission denied: u'C:\\DOCUME~1\\Ed\\LOCALS~1\\Temp\\calibre_qvyjur \\t8yutd_plumber\\index.html'

Can anyone help please?