Can calibre work if installed on D:\, Windows 10?

Had calibre & Alf tools installed on old Windows 7 computer; it worked great for several years. But now have moved to new Windows 10 that has a small C:\ ssd and a huge D:\. Therefore, I am installing most of my programs on D:\, which I did with calibre--but it seems to keep looking for the program on C:\. How can I get it to work on D:\??? Many thanks.